COMPLEXIS – The International Conference on Complexity, Future Information Systems and Risk, aims at becoming a yearly meeting place for presenting and discussing innovative views on all aspects of Complex Information Systems, in different areas such as Informatics, Telecommunications, Computational Intelligence, Biology, Biomedical Engineering and Social Sciences. Information is pervasive in many areas of human activity – perhaps all – and complexity is a characteristic of current Exabyte-sized, highly connected and hyper dimensional, information systems. COMPLEXIS 2019 is expected to provide an overview of the state of the art as well as upcoming trends, and to promote discussion about the potential of new methodologies, technologies and application areas of complex information systems, in the academic and corporate world. COMPLEXIS 2019 seeks papers reporting research work, applications or case-studies, on topics indicated below in the section “Conference Areas”. Papers describing advanced prototypes, systems, tools and techniques and general survey papers indicating future directions are also encouraged. Both technological and social-oriented papers are accepted. All papers must describe original work, not previously published or submitted to another conference. Accepted papers, presented at the conference by one of the authors, will be published in the Proceedings of COMPLEXIS under an ISBN, and will be indexed by major indexes. Acceptance will be based on quality, relevance and originality. Both full research reports (regular papers) and work-in-progress reports (position papers) are welcome. There will be both oral and poster sessions.